Ruthenium-Catalyzed Regioselective Direct Alkylation of Arenes with Unactivated Alkyl Halides through C-H Bond Cleavage

被引：260

作者：

Ackermann, Lutz ^{[1
]}

Novak, Petr ^{[1
]}

Vicente, Ruben ^{[1
]}

Hofmann, Nora ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 33期

关键词：

alkyl halides; alkylation; arenes; C-H bond functionalization; ruthenium; CROSS-COUPLING REACTION; DIRECT ARYLATIONS; GRIGNARD-REAGENTS; ARYL CHLORIDES; FUNCTIONALIZATION; ACTIVATION; PRELIGANDS; PD;

D O I：

10.1002/anie.200902458

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cut to the chase: A ruthenium complex derived from 1- adamantyl carboxylate (1-AdCO2-) enabled highly regioselective intermolecular direct alkylation of arenes with unactivated primary and secondary alkyl halides bearing β-hydrogen atoms (see scheme; NMP=Nmethylpyrrolidinone). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6045 / 6048

页数：4

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