Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors

被引：255

作者：

Minetti, G. C.

Colussi, C.

Adami, R.

Serra, C.

Mozzetta, C.

Parente, V.

Fortuni, S.

Straino, S.

Sampaolesi, M.

Di Padova, M.

Illi, B.

Gallinari, P.

Steinkuehler, C.

Capogrossi, M. C.

Sartorelli, V.

Bottinelli, R.

Gaetano, C.

Puri, P. L.

机构：

[1] Fdn A Cesalpino, Dulbecco Telethon Inst, Inst Cell Biol & Tissue Engn, San Raffaele Biomed Sci Pk Rome, I-00128 Rome, Italy

[2] IRCCS, Ist Dermatopat Immacolata, Lab Vasc Pathol, I-00167 Rome, Italy

[3] Univ Pavia, Dept Expt Med, Human Physiol Unit, I-27100 Pavia, Italy

[4] Univ Pavia, Interuniv Inst Mycol, I-27100 Pavia, Italy

[5] Burnham Inst, La Jolla, CA 92037 USA

[6] Hosp San Raffaele, Stem Cell Res Inst, I-20132 Milan, Italy

[7] NIAMSD, Muscle Gene Express Grp, Muscle Biol Lab, NIH, Bethesda, MD 20892 USA

[8] IRCCS, Lab Vasc Biol & Gene Therapy, Ctr Cardiol Monzino, I-20138 Milan, Italy

[9] Ist Ric Biol Mol P Angeletti, I-00040 Rome, Italy

来源：

NATURE MEDICINE | 2006年 / 12卷 / 10期

关键词：

D O I：

10.1038/nm1479

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pharmacological interventions that increase myofiber size counter the functional decline of dystrophic muscles(1,2). We show that deacetylase inhibitors increase the size of myofibers in dystrophin-deficient (MDX) and alpha-sarcoglycan (alpha-SG)-deficient mice by inducing the expression of the myostatin antagonist follistatin(3) in satellite cells. Deacetylase inhibitor treatment conferred on dystrophic muscles resistance to contraction-coupled degeneration and alleviated both morphological and functional consequences of the primary genetic defect. These results provide a rationale for using deacetylase inhibitors in the pharmacological therapy of muscular dystrophies.

引用

页码：1147 / 1150

页数：4

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