Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity

被引：13

作者：

Angell, A

McGuigan, C

Sevillano, LG

Snoeck, R

Andrei, G

De Clercq, E

Balzarini, J

机构：

[1] Cardiff Univ, Welsh Sch Pharm, Cardiff CF10 3XF, S Glam, Wales

[2] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 10期

关键词：

nucleosides; VZV; bicyclic; antiviral;

D O I：

10.1016/j.bmcl.2004.03.029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thieno analogues of the potent and selective furo-pyrimidine anti-VZV nucleoside family bearing a p-alkylphenyl side chain have been synthesised and tested for their antiviral activity against Varicella-Zoster virus (VZV). While the alkyl chain analogues were shown to retain full antiviral activity against VZV, these new analogues did not when compared to their furo parent nucleosides. (C) 2004 Published by Elsevier Ltd.

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页码：2397 / 2399

页数：3

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