Palladium-catalyzed coupling of ammonia and lithium amide with aryl halides

被引：324

作者：

Shen, Qilong ^{[1
]}

Hartwig, John F. ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 31期

关键词：

D O I：

10.1021/ja064005t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mild, palladium-catalyzed coupling of aryl halides with ammonia or lithium amide to form primary arylamines as the major product is described. These reactions occurred with excellent selectivity for formation of the primary arylamine over formation of the diarylamine (9.5:1 to over 50:1 ratios of arylamine to diarylamine). In addition, the first organopalladium complex with a terminal -NH2 ligand has been isolated. This complex reductively eliminates to form arylamines. Copyright © 2006 American Chemical Society.

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页码：10028 / 10029

页数：2

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