Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked

被引：4250

作者：

Yang, J

Liu, XS

Bhalla, K

Kim, CN

Ibrado, AM

Cai, JY

Peng, TI

Jones, DP

Wang, XD

机构：

[1] UNIV TEXAS, SW MED CTR, DEPT BIOCHEM, DALLAS, TX 75235 USA

[2] EMORY UNIV, SCH MED, DEPT BIOCHEM, ATLANTA, GA 30322 USA

[3] EMORY UNIV, SCH MED,WINSHIP CANC CTR,DEPT MED, DIV HEMATOL ONCOL, ATLANTA, GA 30322 USA

[4] EMORY UNIV, SCH MED, DEPT NEUROL, ATLANTA, GA 30322 USA

来源：

SCIENCE | 1997年 / 275卷 / 5303期

关键词：

D O I：

10.1126/science.275.5303.1129

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bcl-2 is an integral membrane protein located mainly on the outer membrane of mitochondria. Overexpression of Bcl-2 prevents cells from undergoing apoptosis in response to a variety of stimuli. Cytosolic cytochrome c is necessary for the initiation of the apoptotic program, suggesting a possible connection between Bcl-2 and cytochrome c, which is normally located in the mitochondrial intermembrane space. Cells undergoing apoptosis were found to have an elevation of cytochrome c in the cytosol and a corresponding decrease in the mitochondria. Overexpression of Bcl-2 prevented the efflux of cytochrome c from the mitochondria and the initiation of apoptosis. Thus, one possible role of Bcl-2 in prevention of apoptosis is to block cytochrome c release from mitochondria.

引用

页码：1129 / 1132

页数：4

共 37 条

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