HIV-inhibitory natural products .36. Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis

被引：81

作者：

Hallock, YF

Manfredi, KP

Dai, JR

Cardellina, JH

Gulakowski, RJ

McMahon, JB

Schaffer, M

Stahl, M

Gulden, KP

Bringmann, G

Francois, G

Boyd, MR

机构：

[1] UNIV WURZBURG,INST ORGAN CHEM,D-97074 WURZBURG,GERMANY

[2] NCI,DIAG & CTR,DIV CANC TREATMENT,LAB DRUG DISCOVERY RES & DEV,DEV THERAPEUT PROGRAM,FREDERICK,MD 21702

[3] PRINS LEOPOLD INST TROP GENEESKUNDE,B-2000 ANTWERP,BELGIUM

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 07期

关键词：

D O I：

10.1021/np9700679

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation, and CD spectroscopy. Michellamines D-F exhibited in vitro HIV-inhibitory activity comparable to michellamine B, and korupensamine E exhibited in vitro antimalarial activity comparable to korupensamines A-D.

引用

页码：677 / 683

页数：7

共 24 条

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