The Constituents and Their Bioactivities of Houttuynia cordata

被引：65

作者：

Chou, Shu-Chen ^{[1
]}

Su, Chung-Ren ^{[1
]}

Ku, Yuh-Chi ^{[2
]}

Wu, Tian-Shung ^{[1
,3
]}

机构：

[1] Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan

[2] Fu Jen Catholic Univ, Dept Life Sci, Taipei, Taiwan

[3] China Med Univ, Dept Pharm, Taichung 401, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2009年 / 57卷 / 11期

关键词：

Euphorbiaceae; herpes simplex virus type 1; antioxidant; antityrosinase; C-13; NMR-SPECTRA; LEAVES; DERIVATIVES; ALKALOIDS; EPOXIDE; VIRUS;

D O I：

10.1248/cpb.57.1227

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical investigation oil the whole plant of Houttuynia cordata has resulted in the isolation of two new compounds, named as houttuynoside A (1) and houttuynamide A (2), together with thirty-eight known compounds. The structures of I and 2 were elucidated oil the basis of spectroscopic analysis. In the inhibitory effects on herpes simplex virus type I (HSV-1) assay norcepharadione B (10) showed good inhibitory activity against the replication of HSV-1. In addition, the antioxidant and antityrosinase activities of sonic isolated compounds were also evaluated. Among these compounds, quercitrin (25) and quercetin-3-O-beta-D-galactopyrinoside (26) showed excellent 2,2-diphenyl-1-picrylhydrazyl radical-scavenging property with IC50 values of 31 and 63 mu M, respectively. Cepharadione B (9) exhibited strong tyrosinase inhibitory activity with an IC50 value of 170 mu M.

引用

页码：1227 / 1230

页数：4

共 38 条

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