Development of highly effective encapsulating surfactants for Mukaiyama aldol reactions in water

被引：13

作者：

Tian, HY ^{[1
]}

Li, HJ

Chen, YJ

Wang, D

Li, CJ

机构：

[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China

[2] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA

来源：

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH | 2002年 / 41卷 / 18期

关键词：

D O I：

10.1021/ie010782k

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Amphiphilic calix[6]arene derivatives 1a-b and calix[4]arene 1d-1e, as well as aliphatic (2a-b) and aromatic (2c-2d) anionic surfactants, were studied for their encapsulating ability in stabilizing water-sensitive compounds. They were found to be efficient surfactants for Sc(OTf)(3)-catalyzed Mukaiyama aldol reactions of labile enol ethers with aldehydes in water. The results indicate that a hydrophobic microenvironment was formed in the reaction system with either the amphiphilic calix[6]arene derivatives or the simple aromatic surfactants, which could encapsulate and stabilize some labile silyl enol ethers and thus promote the reactions.

引用

页码：4523 / 4527

页数：5

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