BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260

被引：15

作者：

Guo, Zekun

Tang, Wenwen

Yuan, Jian

Chen, Xinya

Wan, Bo

Gu, Xiuting

Luo, Kuntian

Wang, Yingli

Yu, Long ^{[1
]}

机构：

[1] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

[2] NW A&F Univ, Sch Life Sci, Yangling, Shaanxi, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2006年 / 347卷 / 04期

基金：

中国国家自然科学基金;

关键词：

BRSK2; PKA; phosphorylation; AMPK subfamily;

D O I：

10.1016/j.bbrc.2006.06.178

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brain selective kinase 2 (BRSK2) has been identified as a member of AMPK related kinases. LKB1 can phosphorylate the Thr174 of BRSK2, increasing its activity > 50-fold. In this study, we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. The association between these two proteins was confirmed by GST pull-down. Furthermore, our study indicated that the kinase activity of BRSK2 can be increased through phosphorylation by PKA. (c) 2006 Elsevier Inc. All rights reserved.

引用

收藏

页码：867 / 871

页数：5

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