Production of 105Rh-EDTMP and its bone accumulation

被引：25

作者：

Ando, A

Ando, I

Tonami, N

Kinuya, S

Okamoto, N

Sugimoto, M

Fukuda, N

Matsumoto, S

机构：

[1] Kanazawa Univ, Fac Med, Sch Hlth Sci, Kanazawa, Ishikawa 9200942, Japan

[2] Kanazawa Univ, Fac Med, Sch Med, Kanazawa, Ishikawa 9208640, Japan

来源：

APPLIED RADIATION AND ISOTOPES | 2000年 / 52卷 / 02期

关键词：

radiotherapeutic nuclide; rhodium-105; EDTMP; bone metastases;

D O I：

10.1016/S0969-8043(99)00129-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学]; 081704 [应用化学];

摘要：

Rh-105 has favorable physical characteristics as a radiotherapeutic nuclide. Carrier-free Rh-105 be produced by the neutron activation of Ru-104 followed by beta decay of Ru-105. It was clarified that carrier-free Rh-105 can be produced in quantities and the purity necessary for chemical and clinical investigations of its use as a nuclide for radiotherapy. Rh-105-EDTMP was simply obtained from Rh-105(3+) and EDTMP by heating for 30 min in boiling water, giving a radiochemical yield of >99%. Dissociation of radioactivity assessed by paperchromatography was negligible for up to 5 days after its preparation. In animals, Rh-105-EDTMP showed rapid blood clearance and selective uptake in the bone, Hence, Rh-105-EDTMP is thought to be a promising therapeutic agent for the treatment of pain due to bone metastases, (C) 2000 Elsevier Science Ltd, All rights reserved.

引用

页码：211 / 215

页数：5

共 7 条

[1]

177Lu-EDTMP:: A potential therapeutic bone agent [J].