Transcriptional and translational control in the mammalian unfolded protein response

被引：772

作者：

Harding, HP ^{[1
]}

Calfon, M ^{[1
]}

Urano, F ^{[1
]}

Novoa, I ^{[1
]}

Ron, D ^{[1
]}

机构：

[1] NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2002年 / 18卷

关键词：

endoplasmic reticulum; signal transduction; protein processing; molecular chaperones; translation;

D O I：

10.1146/annurev.cellbio.18.011402.160624

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cells monitor the physiological load placed on their endoplasmic reticulum. (ER) and respond to perturbations in ER function by a process known as the unfolded protein response (UPR). In metazoans the UPR has a transcriptional component that up-regulates expression of genes that enhance the capacity of the organelle to deal with the load of client proteins and a translational component that insures tight coupling between protein biosynthesis on the cytoplasmic side and folding in the ER lumen. Together, these two components adapt the secretory apparatus to physiological load and protect cells from the consequences of protein malfolding.

引用

页码：575 / 599

页数：29

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