Phenolic acid amides:: a new type of DNA strand scission agent from Piper caninum

被引：40

作者：

Ma, J

Jones, SH

Hecht, SM ^{[1
]}

机构：

[1] Univ Virginia, Dept Chem, Charlottesville, VA 22901 USA

[2] Univ Virginia, Dept Biol, Charlottesville, VA 22901 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 14期

关键词：

nucleic acids; chemotherapy; natural products;

D O I：

10.1016/j.bmc.2004.05.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

In a survey of the active components of crude plant extracts for their ability to cleave DNA, a crude extract prepared from Piper caninum was found to induce the relaxation of supercoiled pBR322 plasmid DNA in the presence of Cu2+. Bioassay-guided fractionation was carried out on this extract, guided by an in vitro DNA strand scission assay. Three active principles were isolated and identified as N-cis-feruloyl tyramine (1),N-trans-feruloyl tyramine (2), and 1-cinnamoylpyrrolidine (3). Compounds 1-3 represent a structurally new type of DNA strand scission agent. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3885 / 3889

页数：5

共 38 条

[1]

5-ALKYLRESORCINOLS FROM HAKEA-AMPLEXICAULIS THAT CLEAVE DNA [J].