Solid phase synthesis of polyamine conjugates for the study of trypanothione reductase

被引：35

作者：

Marsh, IR ^{[1
]}

Bradley, M ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO17 1BJ,HANTS,ENGLAND

来源：

TETRAHEDRON | 1997年 / 53卷 / 51期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4020(97)10156-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A number of polyamine scaffolds were synthesised, enabling the facile preparation of a variety of polyamine conjugates using both Boc and Fmoc protecting group strategies. Products were released from the solid support by treatment with either triflic acid/trifluoroacetic acid or trifluoroacetic acid. The trypanosomal metabolite N-1, N-8-bis(glutathionyl)spermidine [trypanothione], and a range of related analogues were prepared for biological evaluation as previously communicated. (C) 1997 Elsevier Science Ltd.

引用

页码：17317 / 17334

页数：18

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