A new micro/nanoencapsulated porphyrin formulation for PDT treatment

被引：41

作者：

Deda, Daiana K. ^{[1
]}

Uchoa, Adjaci F. ^{[1
]}

Carita, Eduardo ^{[1
]}

Baptista, Mauricio S. ^{[1
]}

Toma, Henrique E. ^{[1
]}

Araki, Koiti ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Chem, BR-05508000 Sao Paulo, Brazil

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2009年 / 376卷 / 1-2期

基金：

巴西圣保罗研究基金会;

关键词：

Cationic porphyrin; Polymeric encapsulation; PDT; HeLa cells; CATIONIC TETRARUTHENATED PORPHYRIN; N-CONFUSED PORPHYRIN; OF-THE-ART; PHOTODYNAMIC THERAPY; PHOTOPHYSICAL PROPERTIES; PROCESSING PARAMETERS; NANOPARTICLES; DELIVERY; PHOTOSENSITIZERS; COACERVATION;

D O I：

10.1016/j.ijpharm.2009.04.024

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The highly hydrophobic 5,10,15-triphenyl-20-(3-N-methylpyridinium-yl)porphyrin(3MMe)cationic species was synthesized, characterized and encapsulated in marine atelocollagen/xanthane gum microcapsules by the coacervation method. Further reduction in the capsule size, from several microns down to about 300-400 nm, was carried out successfully by ultrasonic processing in the presence of up to 1.6% Tween 20 surfactant, without affecting the distribution of 3MMe in the oily core. The resulting creamlike product exhibited enhanced photodynamic activity but negligible cytotoxicity towards HeLa cells. The polymeric micro/nanocapsule formulation was found to be about 4 times more phototoxic than the respective phosphatidylcholine lipidic emulsion, demonstrating high potentiality for photodynamic therapy applications. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：76 / 83

页数：8

共 46 条

[1]

Bio-nanotechnology and photodynamic therapy - State of the art review [J].

Allison, R. R. ;

Mota, H. C. ;

Bagnato, V. S. ;

Sibata, C. H. .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2008, 5 (01) :19-28

[2]

Zinc tetraruthenated porphyrin binding and photoinduced oxidation of calf-thymus DNA [J].

Araki, K ;

Silva, CA ;

Toma, HE ;

Catalani, LH ;

Medeiros, MHG ;

Di Mascio, P .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2000, 78 (04) :269-273

[3]

Doubly N-confused porphyrins as efficient sensitizers for singlet oxygen generation [J].

Araki, K ;

Engelmann, FM ;

Mayer, I ;

Toma, HE ;

Baptista, MS ;

Maeda, H ;

Osuka, A ;

Furuta, H .

CHEMISTRY LETTERS, 2003, 32 (03) :244-245

[4]

Acid-base and spectroelectrochemical properties of doubly N-confused porphyrins [J].

Araki, K ;

Winnischofer, H ;

Toma, HE ;

Maeda, H ;

Osuka, A ;

Furuta, H .

INORGANIC CHEMISTRY, 2001, 40 (09) :2020-2025

[5]

THE THEORY OF COACERVATION [J].

BAMFORD, CH ;

TOMPA, H .

TRANSACTIONS OF THE FARADAY SOCIETY, 1950, 46 (4-5) :310-316

[6]

Nanoparticles as vehicles for delivery of photodynamic therapy agents [J].

Bechet, Denise ;

Couleaud, Pierre ;

Frochot, Celine ;

Viriot, Marie-Laure ;

Guillemin, Francois ;

Barberi-Heyob, Muriel .

TRENDS IN BIOTECHNOLOGY, 2008, 26 (11) :612-621

[7]

Lipid vesicles and other colloids as drug carriers on the skin [J].

Cevc, G .

ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (05) :675-711

[8]

BIODEGRADABLE PSEUDOLATEXES - THE CHEMICAL-STABILITY OF POLY(D,L-LACTIDE) AND POLY (EPSILON-CAPROLACTONE) NANOPARTICLES IN AQUEOUS-MEDIA [J].

COFFIN, MD ;

MCGINITY, JW .

PHARMACEUTICAL RESEARCH, 1992, 9 (02) :200-205

[9]

Effect of processing parameters on the formation of spherical multinuclear microcapsules encapsulating peppermint oil by coacervation [J].

Dong, Z. J. ;

Toure, A. ;

Jia, C. S. ;

Zhang, X. M. ;

Xu, S. Y. .

JOURNAL OF MICROENCAPSULATION, 2007, 24 (07) :634-646

[10]

PHOTODYNAMIC THERAPY [J].

DOUGHERTY, TJ .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1993, 58 (06) :895-900

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