Structural aspects of the p53 protein in relation to gene evolution: A second look

被引：191

作者：

Soussi, T

May, P

机构：

[1] UNIV PARIS 06,INST GENET MOLEC,F-75010 PARIS,FRANCE

[2] CEA,SDV,DRR,LAB CANCEROGENESE MOLEC,UMR 217,F-92265 FONTENAY ROSES,FRANCE

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1996年 / 260卷 / 05期

关键词：

p53 tumor suppressor gene; transcription factor; conformation flexibility; DNA damage recognition; cell cycle checkpoint;

D O I：

10.1006/jmbi.1996.0425

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several years ago, a comparison of the amino acid sequences of p53 proteins from a variety of species enabled us to reveal structural features of this protein, giving clues to its function. Since then, numerous studies on the biochemical, immunological and biological functions of p53 as well as on its structure (including crystallography data) have provided considerable insight into the multifunctional aspects of p53. The purpose of this review is to present the most recent data concerning the various structural features of the p53 protein with special emphasis on its flexibility, which plays a key role in regulation of its biological activity. (C) 1996 Academic Press Limited

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页码：623 / 637

页数：15

相关论文

共 145 条

[101] NEGATIVE FEEDBACK-REGULATION OF WILD-TYPE P53 BIOSYNTHESIS [J].

MOSNER, J ;

MUMMENBRAUER, T ;

BAUER, C ;

SCZAKIEL, G ;

GROSSE, F ;

DEPPERT, W .

EMBO JOURNAL, 1995, 14 (18) :4442-4449

[102] HUMAN P53 AND CDC2HS GENES COMBINE TO INHIBIT THE PROLIFERATION OF SACCHAROMYCES-CEREVISIAE [J].

NIGRO, JM ;

SIKORSKI, R ;

REED, SI ;

VOGELSTEIN, B .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (03) :1357-1365

[103] CLONING OF FELINE P53 TUMOR-SUPPRESSOR GENE AND ITS ABERRATION IN HEMATOPOIETIC TUMORS [J].

OKUDA, M ;

UMEDA, A ;

SAKAI, T ;

OHASHI, T ;

MOMOI, Y ;

YOUN, HY ;

WATARI, T ;

GOITSUKA, R ;

TSUJIMOTO, H ;

HASEGAWA, A .

INTERNATIONAL JOURNAL OF CANCER, 1994, 58 (04) :602-607

[104] ONCOPROTEIN MDM2 CONCEALS THE ACTIVATION DOMAIN OF TUMOR SUPPRESSOR-P53 [J].

OLINER, JD ;

PIETENPOL, JA ;

THIAGALINGAM, S ;

GVURIS, J ;

KINZLER, KW ;

VOGELSTEIN, B .

NATURE, 1993, 362 (6423) :857-860

[105] MOLECULAR-CLONING OF A CDNA SPECIFIC FOR THE MURINE P53 CELLULAR TUMOR-ANTIGEN [J].

OREN, M ;

LEVINE, AJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (01) :56-59

[106] ANALYSIS OF THE MOST REPRESENTATIVE TUMOR-DERIVED P53 MUTANTS REVEALS THAT CHANGES IN PROTEIN CONFORMATION ARE NOT CORRELATED WITH LOSS OF TRANSACTIVATION OR INHIBITION OF CELL-PROLIFERATION [J].

ORY, K ;

LEGROS, Y ;

AUGUIN, C ;

SOUSSI, T .

EMBO JOURNAL, 1994, 13 (15) :3496-3504

[107] THE DNA-BINDING DOMAIN OF P53 CONTAINS THE 4 CONSERVED REGIONS AND THE MAJOR MUTATION HOT-SPOTS [J].

PAVLETICH, NP ;

CHAMBERS, KA ;

PABO, CO .

GENES & DEVELOPMENT, 1993, 7 (12B) :2556-2564

[108] THE AMINO-ACID-SEQUENCE OF MURINE P53 DETERMINED FROM A C-DNA CLONE [J].

PENNICA, D ;

GOEDDEL, DV ;

HAYFLICK, JS ;

REICH, NC ;

ANDERSON, CW ;

LEVINE, AJ .

VIROLOGY, 1984, 134 (02) :477-482

[109]

PICKSLEY SM, 1994, ONCOGENE, V9, P2523

[110] SEQUENCE-SPECIFIC TRANSCRIPTIONAL ACTIVATION IS ESSENTIAL FOR GROWTH SUPPRESSION BY P53 [J].

PIETENPOL, JA ;

TOKINO, T ;

THIAGALINGAM, S ;

ELDEIRY, WS ;

KINZLER, KW ;

VOGELSTEIN, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (06) :1998-2002

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