Structural aspects of the p53 protein in relation to gene evolution: A second look

被引：191

作者：

Soussi, T

May, P

机构：

[1] UNIV PARIS 06,INST GENET MOLEC,F-75010 PARIS,FRANCE

[2] CEA,SDV,DRR,LAB CANCEROGENESE MOLEC,UMR 217,F-92265 FONTENAY ROSES,FRANCE

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1996年 / 260卷 / 05期

关键词：

p53 tumor suppressor gene; transcription factor; conformation flexibility; DNA damage recognition; cell cycle checkpoint;

D O I：

10.1006/jmbi.1996.0425

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several years ago, a comparison of the amino acid sequences of p53 proteins from a variety of species enabled us to reveal structural features of this protein, giving clues to its function. Since then, numerous studies on the biochemical, immunological and biological functions of p53 as well as on its structure (including crystallography data) have provided considerable insight into the multifunctional aspects of p53. The purpose of this review is to present the most recent data concerning the various structural features of the p53 protein with special emphasis on its flexibility, which plays a key role in regulation of its biological activity. (C) 1996 Academic Press Limited

引用

页码：623 / 637

页数：15

共 145 条

[111]

RAINWATER R, 1995, MOL CELL BIOL, V15, P3892

[112] TRANSCRIPTIONAL ACTIVATION BY WILD-TYPE BUT NOT TRANSFORMING MUTANTS OF THE P53 ANTIONCOGENE [J].