The MLL partial tandem duplication in acute myeloid leukaemia

被引：70

作者：

Basecke, Jorg

Whelan, Jarrett T.

Griesinger, Frank

Bertrand, Fred E.

机构：

[1] Univ Gottingen, Div Haematol & Oncol, Dept Internal Med, D-37075 Gottingen, Germany

[2] E Carolina Univ, Brody Sch Med, Dept Microbiol & Immunol, Greenville, NC USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2006年 / 135卷 / 04期

关键词：

MLL; tandem duplication; acute myeloid leukaemia; leukaemogenesis;

D O I：

10.1111/j.1365-2141.2006.06301.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mixed lineage leukaemia gene-partial tandem duplications (MLL-PTD) characterise acute myeloid leukaemia (AML) with trisomy 11 and AML with a normal karyotype. MLL-PTD confer a worse prognosis with shortened overall and event free survival in childhood and adult AML. In spite of these clinical observations, the leukaemogenic mechanism has, so far, not been determined. This review summarises clinical studies on MLL-PTD positive AML and recent experimental findings on the putative leukaemogenic role of MLL-PTD.

引用

收藏

页码：438 / 449

页数：12

相关论文

共 81 条

[31] Mechanisms of transformation by MLL [J].

Hess, JL .

CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2004, 14 (04) :235-254

[32] Defects in yolk sac hematopoiesis in Mll-null embryos [J].

Hess, JL ;

Yu, BD ;

Li, B ;

Hanson, R ;

Korsmeyer, SJ .

BLOOD, 1997, 90 (05) :1799-1806

[33] Turning on a dimer: New insights into MLL chimeras [J].

Hsu, K ;

Look, AT .

CANCER CELL, 2003, 4 (02) :81-83

[34]

Jamal R, 2001, GENE CHROMOSOME CANC, V31, P187

[35] New insights into MLL gene rearranged acute leukemias using gene expression profiling:: shared pathways, lineage commitment, and partner genes [J].

Kohlmann, A ;

Schoch, C ;

Dugas, M ;

Schnittger, S ;

Hiddemann, W ;

Kern, W ;

Haferlach, T .

LEUKEMIA, 2005, 19 (06) :953-964

[36] Pediatric acute lymphoblastic leukemia (ALL) gene expression signatures classify an independent cohort of adult ALL patients [J].

Kohlmann, A ;

Schoch, C ;

Schnittger, S ;

Dugas, M ;

Hiddemann, W ;

Kern, W ;

Haferlach, T .

LEUKEMIA, 2004, 18 (01) :63-71

[37] Children and adults with acute lymphoblastic leukaemia have similar gene expression profiles [J].

Kuchinskaya, E ;

Heyman, M ;

Grandér, D ;

Linderholm, M ;

Söderhäll, S ;

Zaritskey, A ;

Nordgren, A ;

Porwit-MacDonald, A ;

Zueva, E ;

Pawitan, Y ;

Corcoran, M ;

Nordenskjöld, M ;

Blennow, E .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2005, 74 (06) :466-480

[38] Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia [J].

Kumar, AR ;

Hudson, WA ;

Chen, W ;

Nishiuchi, R ;

Yao, Q ;

Kersey, JH .

BLOOD, 2004, 103 (05) :1823-1828

[39] FLT3 and MLL intragenic abnormalities in AML reflect a common category of genotoxic stress [J].

Libura, M ;

Asnafi, V ;

Tu, A ;

Delabesse, E ;

Tigaud, I ;

Cymbalista, F ;

Bennaceur-Griscelli, A ;

Villarese, P ;

Solbu, G ;

Hagemeijer, A ;

Beldjord, K ;

Hermine, O ;

Macintyre, E .

BLOOD, 2003, 102 (06) :2198-2204

[40]

Marcucci G, 1998, CANCER RES, V58, P790

← 1 2 3 4 5 6 7 8 9 →