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Polycomb silencers control cell fate, development and cancer

被引：1050
作者：
Sparmann, Anke
van Lohuizen, Maarten
机构：
[1] Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands
[2] Netherlands Canc Inst, Ctr Biomed Genet, NL-1066 CX Amsterdam, Netherlands
来源：
NATURE REVIEWS CANCER | 2006年 / 6卷 / 11期
关键词：
D O I：
10.1038/nrc1991
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. Their oncogenic function might be associated with their well-established role in the maintenance of embryonic and adult stem cells. In this review, we discuss new insights into the possible mechanisms by which PcGs regulate cellular identity, and speculate how these functions might be relevant during tumorigenesis.
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页码：846 / 856
页数：11
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