Roles and regulation of Thy-1, a context-dependent modulator of cell phenotype

被引:94
作者
Bradley, James S. [1 ,2 ]
Ramirez, Gustavo [3 ,4 ]
Hagood, James S. [1 ,2 ,5 ]
机构
[1] Univ Alabama, Dept Pediat, Birmingham, AL USA
[2] Univ Alabama, Dept Biochem & Mol Genet, Birmingham, AL USA
[3] Univ Nacl Autonoma Mexico, Dept Cell Biol, Mexico City 04510, DF, Mexico
[4] Inst Nacl Enfermedades Resp, Dept Immunobiol & Genet, Mexico City, DF, Mexico
[5] Univ Alabama, TReNDD, Birmingham, AL USA
关键词
Thy-1; glyocophosphatidylinositol; shedding; epigenetics; REPRODUCTIVE-TRACT FIBROBLASTS; ACTIVATED ENDOTHELIAL-CELLS; SURFACE GLYCOPROTEIN THY-1; ROOT GANGLIONIC NEURONS; HUMAN OVARIAN-CANCER; PULMONARY-FIBROSIS; GRAVES OPHTHALMOPATHY; NEURITE OUTGROWTH; GENE-EXPRESSION; CD90; EXPRESSION;
D O I
10.1002/biof.41
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Thy-1 or CD90 is a glycophosphatidylinositol-linked glycoprotein expressed on the surface of neurons, thymocytes, subsets of fibroblasts, endothelial cells, mesangial cells and some hematopoietic cells. Thy-1 is evolutionarily conserved, developmentally regulated, and often has dramatic effects on cell phenotype; however, the effects vary between and in some cases within cell types and tissues, and between similar tissues in different species, indicating that the biological role of Thy-1 is context-dependent. Thy-1 exists in soluble form in some body fluids; however, the mechanisms of its shedding are unknown. In addition, Thy-1 expression can be regulated by epigenetic silencing. Because Thy-1 modulates many basic cellular processes and is involved in the pathogenesis of a number of diseases, it is important to better understand its regulation. (C) 2009 International Union of Biochemistry and Molecular Biology, Inc. Volume 35, Number 3, May/June 2009, Pages 258-265. E-mail: ihagood@uab.edu
引用
收藏
页码:258 / 265
页数:8
相关论文
共 69 条
[21]   HUMAN THY-1 - EXPRESSION ON THE CELL-SURFACE OF NEURONAL AND GLIAL-CELLS [J].
KEMSHEAD, JT ;
RITTER, MA ;
COTMORE, SF ;
GREAVES, MF .
BRAIN RESEARCH, 1982, 236 (02) :451-461
[22]   Evidence for Enhanced Thy-1 (CD90) Expression in Orbital Fibroblasts of Patients with Graves' Ophthalmopathy [J].
Khoo, Teck Kim ;
Coenen, Michael J. ;
Schiefer, A. Reagan ;
Kumar, Seema ;
Bahn, Rebecca S. .
THYROID, 2008, 18 (12) :1291-1296
[23]   T-cell regulation: Thy-1-hiding in full view [J].
Killeen, N .
CURRENT BIOLOGY, 1997, 7 (12) :R774-R777
[24]   Idiopathic pulmonary fibrosis - Relationship between histopathologic features and mortality [J].
King, TE ;
Schwarz, MI ;
Brown, K ;
Tooze, JA ;
Colby, TV ;
Waldron, JA ;
Flint, A ;
Thurlbeck, W ;
Cherniack, RM .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 164 (06) :1025-1032
[25]   Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes [J].
Koumas, L ;
Smith, TJ ;
Feldon, S ;
Blumberg, N ;
Phipps, RP .
AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (04) :1291-1300
[26]   Differential COX localization and PG release in Thy-1+ and Thy-1- human female reproductive tract fibroblasts [J].
Koumas, L ;
Phipps, RP .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2002, 283 (02) :C599-C608
[27]   Fibroblast heterogeneity -: Existence of functionally distinct Thy 1+ and Thy 1- human female reproductive tract fibroblasts [J].
Koumas, L ;
King, AE ;
Critchley, HOD ;
Kelly, RW ;
Phipps, RP .
AMERICAN JOURNAL OF PATHOLOGY, 2001, 159 (03) :925-935
[28]  
Kukulansky T, 1999, J IMMUNOL, V162, P5993
[29]   DYNAMICS AND LONGEVITY OF THE GLYCOLIPID-ANCHORED MEMBRANE-PROTEIN, THY-1 [J].
LEMANSKY, P ;
FATEMI, SH ;
GORICAN, B ;
MEYALE, S ;
ROSSERO, R ;
TARTAKOFF, AM .
JOURNAL OF CELL BIOLOGY, 1990, 110 (05) :1525-1531
[30]   Thy-1 binds to integrin β3 on astrocytes and triggers formation of focal contact sites [J].
Leyton, L ;
Schneider, P ;
Labra, CV ;
Rüegg, C ;
Hetz, CA ;
Quest, AFG ;
Bron, C .
CURRENT BIOLOGY, 2001, 11 (13) :1028-1038