Food groups and risk of prostate cancer in Italy

被引:69
作者
Bosetti, C
Micelotta, S
Dal Maso, L
Talamini, R
Montella, M
Negri, E
Conti, E
Francheschi, S
La Vecchia, C
机构
[1] Ist Ric Farmacol Mario Negri, Lab Epidemiol, I-20157 Milan, Italy
[2] Ctr Riferimento Oncol, Serv Epidemiol & Biostat, I-33081 Aviano, Italy
[3] Ist Tumori Fdn Pascale, Serv Epidemiol, Naples, Italy
[4] Serv Integrato Epidemiol & Sistemi Informativi, Rome, Italy
[5] Int Agcy Res Canc, F-69372 Lyon, France
[6] Univ Milan, Ist Stat Med & Biometria, I-20122 Milan, Italy
关键词
prostate cancer; diet; risk factor; case-control study;
D O I
10.1002/ijc.20142
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Although several studies have been conducted, the relation between diet and prostate cancer remains unclear. The role of a wide range of foods on the risk of prostate cancer has thus been analyzed in a case-control study conducted in Italy between 1991 and 2002. Cases were 1,294 patients below age 75 years with incident, histologically confirmed carcinoma of the prostate; controls were 1,451 subjects below age 75 years admitted to the same hospitals as cases for a wide spectrum of acute, non-neoplastic conditions. Multivariate odds ratios (ORs) were obtained after allowance for major potential confounding factors, including calorie intake. Among the 19 food groups considered, 4 showed some significant association with prostate cancer risk. A significant trend of increasing risk with more frequent consumption was found for milk and dairy products (OR = 1.2 for highest vs. lowest quintile, p = 0.03) as well as bread (OR = 1.4, p = 0.01), whereas inverse associations were observed for soups (OR = 0.8, p = 0.02) and cooked vegetables (OR = 0.7, p = 0.01). This uniquely large study on prostate cancer and diet in a southern European population confirms that no strong association exists between any specific foods and prostate cancer, apart from an increased risk for milk and dairy products and a possible protective effect of vegetables. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码:424 / 428
页数:5
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