Pharmacology and potential therapeutic applications of nitric oxide-releasing non-steroidal anti-inflammatory and related nitric oxide-donating drugs

被引：155

作者：

Keeble, JE ^{[1
]}

Moore, PK ^{[1
]}

机构：

[1] Kings Coll London, Ctr Cardiovasc Biol & Med, London SE1 9RT, England

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2002年 / 137卷 / 03期

关键词：

nitric oxide; non-steroidal anti-inflammatory drug; gastrointestinal; ulcers; pain; inflammation; colitis; cancer; asthma; liver;

D O I：

10.1038/sj.bjp.0704876

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review examines the biological significance, therapeutic potential and mechanism(s) of action of a range of nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAID) and related nitric oxide-releasing donating drugs (NODD). The slow release of nitric oxide (NO) from these compounds leads to subtle changes in the profile of pharmacological activity of the parent, nonsteroidal anti-inflammatory drugs (NSAID). For example, compared with NSAID, NO-NSAID cause markedly diminished gastrointestinal toxicity and improved anti-inflammatory and anti-nociceptive efficacy. In addition, nitroparacetamol exhibits hepatoprotection as opposed to the hepatotoxic activity of paracetamol. The possibility that NO-NSAID or NODD may be of therapeutic benefit in a wide variety of disease states including pain and inflammation, thrombosis and restenosis, neurodegenerative diseases of the central nervous system, colitis, cancer, urinary incontinence, liver disease, impotence, bronchial asthma and osteoporosis is discussed.

引用

页码：295 / 310

页数：16

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