Reverse-genetic approaches to the study of Borna disease virus

被引:19
作者
de la Torre, Juan C. [1 ]
机构
[1] Scripps Res Inst, Mol Integrat Neurosci Dept IMM6, La Jolla, CA 92037 USA
关键词
D O I
10.1038/nrmicro1489
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Borna disease virus (BDV) is an enveloped virus that has a non-segmented, negative-strand RNA genome with the characteristic organization of the mononegaviruses. However, based on its unique genetic and biological features, BDV is considered to be the prototypic member of a new mononegavirus family, the Bornaviridae. BDV causes central nervous system (CNS) disease in a wide variety of mammals. This article discusses the recently developed reverse-genetics systems for BDV, and the implications for the elucidation of the molecular mechanisms underlying BDV-host interactions, including the basis of BDV persistence in the CNS and its associated diseases.
引用
收藏
页码:777 / 783
页数:7
相关论文
共 89 条
[1]   1-β-D-arabinofuranosylcytosine inhibits Borna disease virus replication and spread [J].
Bajramovic, JJ ;
Syan, S ;
Brahic, M ;
de la Torre, JC ;
Gonzalez-Dunia, D .
JOURNAL OF VIROLOGY, 2002, 76 (12) :6268-6276
[2]   Bunyamwera bunyavirus RNA synthesis requires cooperation of 3′- and 5′-terminal sequences [J].
Barr, JN ;
Wertz, GW .
JOURNAL OF VIROLOGY, 2004, 78 (03) :1129-1138
[3]   High-avidity human serum antibodies recognizing linear epitopes of Borna disease virus proteins [J].
Billich, C ;
Sauder, C ;
Frank, R ;
Herzog, S ;
Bechter, K ;
Takahashi, K ;
Peters, H ;
Staeheli, P ;
Schwemmle, M .
BIOLOGICAL PSYCHIATRY, 2002, 51 (12) :979-987
[4]   GENOMIC ORGANIZATION OF BORNA-DISEASE VIRUS [J].
BRIESE, T ;
SCHNEEMANN, A ;
LEWIS, AJ ;
PARK, YS ;
KIM, S ;
LUDWIG, H ;
LIPKIN, WI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (10) :4362-4366
[5]   The RNA polymerase of influenza A virus is stabilized by interaction with its viral RNA promoter [J].
Brownlee, GG ;
Sharps, JL .
JOURNAL OF VIROLOGY, 2002, 76 (14) :7103-7113
[6]   Borna disease virus and human disease [J].
Carbone, KM .
CLINICAL MICROBIOLOGY REVIEWS, 2001, 14 (03) :513-+
[7]   RESCUE OF SYNTHETIC ANALOGS OF RESPIRATORY SYNCYTIAL VIRUS GENOMIC RNA AND EFFECT OF TRUNCATIONS AND MUTATIONS ON THE EXPRESSION OF A FOREIGN REPORTER GENE [J].
COLLINS, PL ;
MINK, MA ;
STEC, DS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (21) :9663-9667
[8]  
Conzelmann KK, 2004, CURR TOP MICROBIOL, V283, P1
[9]   Trafficking of viral genomic RNA into and out of the nucleus: influenza, Thogoto and Borna disease viruses [J].
Cros, JF ;
Palese, P .
VIRUS RESEARCH, 2003, 95 (1-2) :3-12
[10]   RNA SPLICING CONTRIBUTES TO THE GENERATION OF MATURE MESSENGER-RNAS OF BORNA-DISEASE VIRUS, A NONSEGMENTED NEGATIVE STRAND RNA VIRUS [J].
CUBITT, B ;
OLDSTONE, C ;
VALCARCEL, J ;
DELATORRE, JC .
VIRUS RESEARCH, 1994, 34 (01) :69-79