Reverse-genetic approaches to the study of Borna disease virus

被引：19

作者：

de la Torre, Juan C. ^{[1
]}

机构：

[1] Scripps Res Inst, Mol Integrat Neurosci Dept IMM6, La Jolla, CA 92037 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2006年 / 4卷 / 10期

关键词：

D O I：

10.1038/nrmicro1489

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Borna disease virus (BDV) is an enveloped virus that has a non-segmented, negative-strand RNA genome with the characteristic organization of the mononegaviruses. However, based on its unique genetic and biological features, BDV is considered to be the prototypic member of a new mononegavirus family, the Bornaviridae. BDV causes central nervous system (CNS) disease in a wide variety of mammals. This article discusses the recently developed reverse-genetics systems for BDV, and the implications for the elucidation of the molecular mechanisms underlying BDV-host interactions, including the basis of BDV persistence in the CNS and its associated diseases.

引用

页码：777 / 783

页数：7

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