Reverse-genetic approaches to the study of Borna disease virus

被引:19
作者
de la Torre, Juan C. [1 ]
机构
[1] Scripps Res Inst, Mol Integrat Neurosci Dept IMM6, La Jolla, CA 92037 USA
关键词
D O I
10.1038/nrmicro1489
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Borna disease virus (BDV) is an enveloped virus that has a non-segmented, negative-strand RNA genome with the characteristic organization of the mononegaviruses. However, based on its unique genetic and biological features, BDV is considered to be the prototypic member of a new mononegavirus family, the Bornaviridae. BDV causes central nervous system (CNS) disease in a wide variety of mammals. This article discusses the recently developed reverse-genetics systems for BDV, and the implications for the elucidation of the molecular mechanisms underlying BDV-host interactions, including the basis of BDV persistence in the CNS and its associated diseases.
引用
收藏
页码:777 / 783
页数:7
相关论文
共 89 条
[11]   SEQUENCE AND GENOME ORGANIZATION OF BORNA-DISEASE VIRUS [J].
CUBITT, B ;
OLDSTONE, C ;
DELATORRE, JC .
JOURNAL OF VIROLOGY, 1994, 68 (03) :1382-1396
[12]   BORNA-DISEASE VIRUS (BDV), A NONSEGMENTED RNA VIRUS, REPLICATES IN THE NUCLEI OF INFECTED-CELLS WHERE INFECTIOUS BDV RIBONUCLEOPROTEINS ARE PRESENT [J].
CUBITT, B ;
DELATORRE, JC .
JOURNAL OF VIROLOGY, 1994, 68 (03) :1371-1381
[13]   Identification and characterization of a new intron in Borna disease virus [J].
Cubitt, B ;
Ly, C ;
de la Torre, JC .
JOURNAL OF GENERAL VIROLOGY, 2001, 82 :641-646
[14]   MOLECULAR-BIOLOGY OF BORNA-DISEASE VIRUS - PROTOTYPE OF A NEW GROUP OF ANIMAL VIRUSES [J].
DELATORRE, JC .
JOURNAL OF VIROLOGY, 1994, 68 (12) :7669-7675
[15]   Borna disease virus (BDV) sequences derived from plasma samples of Australian cats contain multiple sequencing errors and are otherwise almost identical to strain V, a commonly used BDV laboratory strain [J].
Duerrwald, Ralf ;
Kolodziejek, Jolanta ;
Nowotny, Norbert .
MICROBES AND INFECTION, 2006, 8 (05) :1421-1422
[16]   Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations [J].
Duerrwald, Ralf ;
Kolodziejek, Jolanta ;
Muluneh, Aemero ;
Herzog, Sibylle ;
Nowotny, Norbert .
MICROBES AND INFECTION, 2006, 8 (03) :917-929
[17]   Maturation of Borna disease virus glycoprotein [J].
Eickmann, M ;
Kiermayer, S ;
Kraus, I ;
Gössl, M ;
Richt, JA ;
Garten, W .
FEBS LETTERS, 2005, 579 (21) :4751-4756
[18]   Interaction of influenza virus polymerase with viral RNA in the 'corkscrew' conformation [J].
Flick, R ;
Hobom, G .
JOURNAL OF GENERAL VIROLOGY, 1999, 80 :2565-2572
[19]   Letter to the Editor refuting "Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations" by Ralf Durrwald, Jolanta Kolodziejek, Aemero Muluneh, Sibylle Herzog and Norbert Nowotny, Microbes and Infection 8 (2006) 917-929 [J].
Flower, R ;
Kamhieh, S .
MICROBES AND INFECTION, 2006, 8 (05) :1419-1420
[20]   EUKARYOTIC TRANSIENT-EXPRESSION SYSTEM BASED ON RECOMBINANT VACCINIA VIRUS THAT SYNTHESIZES BACTERIOPHAGE-T7 RNA-POLYMERASE [J].
FUERST, TR ;
NILES, EG ;
STUDIER, FW ;
MOSS, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (21) :8122-8126