Asymmetric 1,3-dipolar cycloaddition: Synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester

被引：26

作者：

Gefflaut, T

Bauer, U

Airola, K

Koskinen, AMP

机构：

[1] UNIV OULU,DEPT CHEM,FIN-90571 OULU,FINLAND

[2] UNIV JYVASKYLA,DEPT CHEM,FIN-40351 JYVASKYLA,FINLAND

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 11期

关键词：

D O I：

10.1016/0957-4166(96)00407-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An asymmetric synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester is described. The key feature of the synthesis is the asymmetric 1,3-dipolar cycloaddition of nitrone 4 with 5, which provides stereoselectively the isoxazolidine with the correct stereochemistry suitable for the synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester 1. Copyright (C) 1996 Elsevier Science Ltd

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页码：3099 / 3102

页数：4

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