An improved method for the preparation of [11C]verapamil

被引：29

作者：

Wegman, TD ^{[1
]}

Maas, B ^{[1
]}

Elsinga, PH ^{[1
]}

Vaalburg, W ^{[1
]}

机构：

[1] Univ Groningen Hosp, Positron Emiss Tomog Ctr, PET, NL-9700 RB Groningen, Netherlands

来源：

APPLIED RADIATION AND ISOTOPES | 2002年 / 57卷 / 04期

关键词：

multidrug resistance (MDR); P-glycoprotein; C-11]verapamil; positron emission tomography;

D O I：

10.1016/S0969-8043(02)00143-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This paper describes an improved preparation of [C-11]verapamil by reaction of [C-11]methyl triflate with desmethylverapamil. The optimal reaction temperature, amount of precursor and reaction time were assessed. With this method [C-11]verapamil can be prepared with a reproducible radiochemical yield of 66+/-4% (EOB, based on [C-11]methyltriflate). Total synthesis time was 60 min. Radiochemical purity was >99% and specific activities varied between 5 and 30TBq/mmol. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：505 / 507

页数：3

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