'Diam-BINAP';: a highly efficient monomer for the synthesis of heterogeneous enantioselective catalysts

被引：53

作者：

ter Halle, R

Colasson, B

Schulz, E

Spagnol, M

Lemaire, M

机构：

[1] Univ Lyon 1, Lab Catalyse & Synth Organ, IRC, CPE, F-69622 Villeurbanne, France

[2] Rhone Poulenc Rech, CRIT Carrieres, F-69192 St Fons, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 05期

关键词：

asymmetric reactions; hydrogenation; polymer support; ruthenium;

D O I：

10.1016/S0040-4039(99)02129-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a monomeric analogue of BINAP, diam-BINAP, is described. The polyaddition of this monomer with 2,6-diisocyanato toluene gave the corresponding oligomer, poly-NAP, with a polymerization degree of 8. The ruthenium complex of this polymer proved to be a very efficient heterogeneous catalyst for the hydrogenation of beta-ketoesters (99% ee, 0.1 mol% of catalyst). Furthermore the catalyst could be easily reused four times by simple filtration without loss of activity or enantioselectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：643 / 646

页数：4

共 14 条

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