Immobilization stress increases mRNA levels of interleukin-1 receptor antagonist in various rat brain regions

被引：48

作者：

Suzuki, E ^{[1
]}

Shintani, F ^{[1
]}

Kanba, S ^{[1
]}

Asai, M ^{[1
]}

Nakaki, T ^{[1
]}

机构：

[1] KEIO UNIV, SCH MED, DEPT PHARMACOL, SHINJUKU KU, TOKYO 160, JAPAN

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 1997年 / 17卷 / 05期

关键词：

interleukin-1; beta; interleukin-1 receptor antagonist; immobilization stress; reverse transcription polymerase chain reaction; brain;

D O I：

10.1023/A:1026319107528

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

1. Interleukin-1 receptor antagonist (IL-1Ra), as well as the interleukin-1 beta (IL-1 beta) gene response to immobilization stress (IMS), was examined in the rat brain. The reverse transcription-polymerase chain reaction was employed to determine mRNA levels. 2. IL-1 beta and IL-1Ra mRNA levels peaked at approximately 0.5 and 2-4 hr, respectively. The maximum mRNA levels of IL-1 beta were 15-fold higher than pre-IMS levels, whereas those of IL-1Ra were 250-fold higher in the hypothalamus. 3. After the biosynthesis of IL-1 beta has peaked, IL-1Ra may contribute to attenuation of the IL-1 activity which has been enhanced by IMS.

引用

页码：557 / 562

页数：6

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