Inflammation and metabolic disorders

被引：6640

作者：

Hotamisligil, Goekhan S. ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

来源：

NATURE | 2006年 / 444卷 / 7121期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature05485

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare.

引用

页码：860 / 867

页数：8

共 99 条

[61] Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
Oezcan, Umut
Yilmaz, Erkan
Oezcan, Lale
Furuhashi, Masato
Vaillancourt, Eric
Smith, Ross O.
Goerguen, Cem Z.
Hotamisligil, Goekhan S.
[J]. SCIENCE, 2006, 313 (5790) : 1137 - 1140
[62] Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM
Ofei, F
Hurel, S
Newkirk, J
Sopwith, M
Taylor, R
[J]. DIABETES, 1996, 45 (07) : 881 - 885
[63] Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
Ogawa, S
Lozach, J
Benner, C
Pascual, G
Tangirala, RK
Westin, S
Hoffmann, A
Subramaniam, S
David, M
Rosenfeld, MG
Glass, CK
[J]. CELL, 2005, 122 (05) : 707 - 721
[64] The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes
Ozawa, K
Miyazaki, M
Matsuhisa, M
Takano, K
Nakatani, Y
Hatazaki, M
Tamatani, T
Yamagata, K
Miyagawa, JI
Kitao, Y
Hori, O
Yamasaki, Y
Ogawa, S
[J]. DIABETES, 2005, 54 (03) : 657 - 663
[65] Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
Özcan, U
Cao, Q
Yilmaz, E
Lee, AH
Iwakoshi, NN
Özdelen, E
Tuncman, G
Görgün, C
Glimcher, LH
Hotamisligil, GS
[J]. SCIENCE, 2004, 306 (5695) : 457 - 461
[66] Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
Paz, K
Hemi, R
LeRoith, D
Karasik, A
Elhanany, E
Kanety, H
Zick, Y
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (47) : 29911 - 29918
[67] Western diet modulates insulin signaling, c-jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion
Prada, PO
Zecchin, HG
Gasparetti, AL
Torsoni, MA
Ueno, M
Hirata, AE
do Amaral, MEC
Höer, NF
Boschero, AC
Saad, MJA
[J]. ENDOCRINOLOGY, 2005, 146 (03) : 1576 - 1587
[68] Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis
Ricci, R
Sumara, G
Sumara, I
Rozenberg, I
Kurrer, M
Akhmedov, A
Hersberger, M
Eriksson, U
Eberli, FR
Becher, B
Borén, J
Chen, M
Cybulsky, MI
Moore, KJ
Freeman, MW
Wagner, EF
Matter, CM
Lüscher, TF
[J]. SCIENCE, 2004, 306 (5701) : 1558 - 1561
[69] Childhood obesity and a diabetes epidemic
Rocchini, AP
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (11) : 854 - 855
[70] PPARγ:: a nuclear regulator of metabolism, differentiation, and cell growth
Rosen, ED
Spiegelman, BM
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (41) : 37731 - 37734

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