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Inflammation and metabolic disorders

被引：6640
作者：
Hotamisligil, Goekhan S. [1 ]
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA
来源：
NATURE | 2006年 / 444卷 / 7121期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nature05485
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare.
引用
收藏
页码：860 / 867
页数：8
相关论文
共 99 条
  • [51] Liu Gang, 2005, Curr Opin Investig Drugs, V6, P979
  • [52] NF-κB is required for UV-induced JNK activation via induction of PKCδ
    Liu, J
    Yang, D
    Minemoto, Y
    Leitges, M
    Rosner, MR
    Lin, A
    [J]. MOLECULAR CELL, 2006, 21 (04) : 467 - 480
  • [53] Mitochondrial dysfunction and type 2 diabetes
    Lowell, BB
    Shulmanz, GI
    [J]. SCIENCE, 2005, 307 (5708) : 384 - 387
  • [54] Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes
    Maeda, K
    Cao, HM
    Kono, K
    Gorgun, CZ
    Furuhashi, M
    Uysal, KT
    Cao, Q
    Atsumi, G
    Malone, H
    Krishnan, B
    Minokoshi, Y
    Kahn, BB
    Parker, RA
    Hotamisligil, GS
    [J]. CELL METABOLISM, 2005, 1 (02) : 107 - 119
  • [55] Functional delivery of a cytosolic tRNA into mutant mitochondria of human cells
    Mahata, Bidesh
    Mukherjee, Saikat
    Mishra, Sumita
    Bandyopadhyay, Arun
    Adhya, Samit
    [J]. SCIENCE, 2006, 314 (5798) : 471 - 474
  • [56] Fatty acid binding proteins - The evolutionary crossroads of inflammatory and metabolic responses
    Makowski, L
    Hotamisligil, GS
    [J]. JOURNAL OF NUTRITION, 2004, 134 (09) : 2464S - 2468S
  • [57] Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
    Makowski, L
    Boord, JB
    Maeda, K
    Babaev, VR
    Uysal, KT
    Morgan, MA
    Parker, RA
    Suttles, J
    Fazio, S
    Hotamisligil, GS
    Linton, MF
    [J]. NATURE MEDICINE, 2001, 7 (06) : 699 - 705
  • [58] Endoplasmic reticulum stress signaling in disease
    Marciniak, Stefan J.
    Ron, David
    [J]. PHYSIOLOGICAL REVIEWS, 2006, 86 (04) : 1133 - 1149
  • [59] PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    Mootha, VK
    Lindgren, CM
    Eriksson, KF
    Subramanian, A
    Sihag, S
    Lehar, J
    Puigserver, P
    Carlsson, E
    Ridderstråle, M
    Laurila, E
    Houstis, N
    Daly, MJ
    Patterson, N
    Mesirov, JP
    Golub, TR
    Tamayo, P
    Spiegelman, B
    Lander, ES
    Hirschhorn, JN
    Altshuler, D
    Groop, LC
    [J]. NATURE GENETICS, 2003, 34 (03) : 267 - 273
  • [60] Involvement of endoplasmic reticulum stress in insulin resistance and diabetes
    Nakatani, Y
    Kaneto, H
    Kawamori, D
    Yoshiuchi, K
    Hatazaki, M
    Matsuoka, T
    Ozawa, K
    Ogawa, S
    Hori, M
    Yamasaki, Y
    Matsuhisa, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (01) : 847 - 851
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