Novel synthetic approach to 1 alpha,24(R)-dihydroxyvitamin D-3 using an asymmetric nitroaldol reaction

被引：24

作者：

Oshida, J ^{[1
]}

Okamoto, M ^{[1
]}

Azuma, S ^{[1
]}

Tanaka, T ^{[1
]}

机构：

[1] TEIJIN LTD,IWAKUNI PHARMACEUT FACTORY,CHEM MFG PLANT,YAMAGUCHI 740,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 15期

关键词：

D O I：

10.1016/S0957-4166(97)00312-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Rare earth-K-(S)-BINOL complexes were used to catalyze the nitroaldol reaction of the CD-ring 24-aldehyde precursors with 2-nitropropane in a good stereoselective manner. The obtained nitroaldol compound was easily converted into a synthetic intermediate 12 of 1 alpha,24(R)-dihydroxyvitamin D-3 1 by a denitration reaction using 2,2'-azobisisobutyronitrile (AIBN) and Bu3SnH. (C) 1997 Elsevier Science Ltd.

引用

页码：2579 / 2584

页数：6

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