Metalloaminopeptidases: Common functional themes in disparate structural surroundings

被引：282

作者：

Lowther, WT

Matthews, BW

机构：

[1] Howard Hughes Med Inst, Inst Mol Biol, Eugene, OR 97403 USA

[2] Univ Oregon, Dept Phys, Eugene, OR 97403 USA

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 12期

关键词：

D O I：

10.1021/cr0101757

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metalloaminopeptidases... This review describes the contributions of many laboratories as they have sought to understand the molecular basis for substrate specificity and catalysis. An effort is made to give sufficient historical background to appreciate the current state of knowledge. The structure-function relationships for each enzyme system are presented based on the analysis of substrate specificity, metal dependence, and the comparison of ligand complexes determined by X-ray crystallography, when available.

引用

收藏

页码：4581 / 4607

页数：27

相关论文

共 212 条

[1] KINETIC-PARAMETERS OF METAL-SUBSTITUTED LEUCINE AMINOPEPTIDASE FROM BOVINE LENS [J].

ALLEN, MP ;

YAMADA, AH ;

CARPENTER, FH .

BIOCHEMISTRY, 1983, 22 (16) :3778-3783

[2] ALPHA-AMINOALDEHYDES - TRANSITION-STATE ANALOG INHIBITORS OF LEUCINE AMINOPEPTIDASE [J].

ANDERSSON, L ;

ISLEY, TC ;

WOLFENDEN, R .

BIOCHEMISTRY, 1982, 21 (17) :4177-4180

[3] USE OF SECONDARY ISOTOPE EFFECTS AND VARYING PH TO INVESTIGATE THE MODE OF BINDING OF INHIBITOR AMINO ALDEHYDES BY LEUCINE AMINOPEPTIDASE [J].

ANDERSSON, L ;

MACNEELA, J ;

WOLFENDEN, R .

BIOCHEMISTRY, 1985, 24 (02) :330-333

[4]

ANTONOV VK, 1981, EUR J BIOCHEM, V117, P195

[5] EUKARYOTIC METHIONYL AMINOPEPTIDASES - 2 CLASSES OF COBALT-DEPENDENT ENZYMES [J].

ARFIN, SM ;

KENDALL, RL ;

HALL, L ;

WEAVER, LH ;

STEWART, AE ;

MATTHEWS, BW ;

BRADSHAW, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) :7714-7718

[6] 3-DIMENSIONAL STRUCTURAL RESEMBLANCE BETWEEN LEUCINE AMINOPEPTIDASE AND CARBOXYPEPTIDASE-A REVEALED BY GRAPH-THEORETICAL TECHNIQUES [J].

ARTYMIUK, PJ ;

GRINDLEY, HM ;

PARK, JE ;

RICE, DW ;

WILLETT, P .

FEBS LETTERS, 1992, 303 (01) :48-52

[7] HYDROXAMATES AND ALIPHATIC BORONIC ACIDS - MARKER INHIBITORS FOR AMINOPEPTIDASE [J].

BAKER, JO ;

WILKES, SH ;

BAYLISS, ME ;

PRESCOTT, JM .

BIOCHEMISTRY, 1983, 22 (09) :2098-2103

[8] MODIFIED ACTIVITY OF AEROMONAS AMINOPEPTIDASE - METAL-ION SUBSTITUTIONS AND ROLE OF SUBSTRATES [J].

BAYLISS, ME ;

PRESCOTT, JM .

BIOCHEMISTRY, 1986, 25 (24) :8113-8117

[9] SEQUENCE AND STRUCTURE COMPARISON SUGGEST THAT METHIONINE AMINOPEPTIDASE, PROLIDASE, AMINOPEPTIDASE-P, AND CREATINASE SHARE A COMMON FOLD [J].

BAZAN, JF ;

WEAVER, LH ;

RODERICK, SL ;

HUBER, R ;

MATTHEWS, BW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (07) :2473-2477

[10]

Ben-Bassat A, 1991, Bioprocess Technol, V12, P147

← 1 2 3 4 5 6 7 8 9 10 →