Metalloaminopeptidases: Common functional themes in disparate structural surroundings

被引：282

作者：

Lowther, WT

Matthews, BW

机构：

[1] Howard Hughes Med Inst, Inst Mol Biol, Eugene, OR 97403 USA

[2] Univ Oregon, Dept Phys, Eugene, OR 97403 USA

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 12期

关键词：

D O I：

10.1021/cr0101757

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metalloaminopeptidases... This review describes the contributions of many laboratories as they have sought to understand the molecular basis for substrate specificity and catalysis. An effort is made to give sufficient historical background to appreciate the current state of knowledge. The structure-function relationships for each enzyme system are presented based on the analysis of substrate specificity, metal dependence, and the comparison of ligand complexes determined by X-ray crystallography, when available.

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收藏

页码：4581 / 4607

页数：27

相关论文

共 212 条

[91] Serum leucine aminopeptidase as an activity indicator in systemic lupus erythematosus: a study of 46 consecutive cases [J].

Inokuma, S ;

Setoguchi, K ;

Ohta, T ;

Matsuzaki, Y ;

Yoshida, A .

RHEUMATOLOGY, 1999, 38 (08) :705-708

[92] ROLE OF METHIONINE IN INITIATION OF HAEMOGLOBIN SYNTHESIS [J].

JACKSON, R ;

HUNTER, T .

NATURE, 1970, 227 (5259) :672-&

[93]

Johnson MJ, 1936, J BIOL CHEM, V116, P515

[94] Investigation of the metal binding site in methionine aminopeptidase by density functional theory [J].

Jorgensen, AT ;

Norrby, PO ;

Liljefors, T .

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2002, 16 (03) :167-179

[95] Structure of a unique binuclear manganese cluster in arginase [J].

Kanyo, ZF ;

Scolnick, LR ;

Ash, DE ;

Christianson, DW .

NATURE, 1996, 383 (6600) :554-557

[96] Synthesis of (3R)-amino-(2S)-hydroxy amino acids for inhibition of methionine aminopeptidase-1 [J].

Keding, SJ ;

Dales, NA ;

Lim, SJ ;

Beaulieu, D ;

Rich, DH .

SYNTHETIC COMMUNICATIONS, 1998, 28 (23) :4463-4470

[97]

KENDALL RL, 1992, J BIOL CHEM, V267, P20667

[98] SIGNIFICANCE OF ZINC IN LEUCINE AMINOPEPTIDASE FROM BOVINE LENSES [J].

KETTMANN, U ;

HANSON, H .

FEBS LETTERS, 1970, 10 (01) :17-&

[99] X-RAY CRYSTALLOGRAPHIC DETERMINATION OF THE STRUCTURE OF BOVINE LENS LEUCINE AMINOPEPTIDASE COMPLEXED WITH AMASTATIN - FORMULATION OF A CATALYTIC MECHANISM FEATURING A GEM-DIOLATE TRANSITION-STATE [J].

KIM, H ;

LIPSCOMB, WN .

BIOCHEMISTRY, 1993, 32 (33) :8465-8478

[100] COMPARISON OF THE STRUCTURES OF 3 CARBOXYPEPTIDASE-A PHOSPHONATE COMPLEXES DETERMINED BY X-RAY CRYSTALLOGRAPHY [J].

KIM, HD ;

LIPSCOMB, WN .

BIOCHEMISTRY, 1991, 30 (33) :8171-8180

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