Metalloaminopeptidases: Common functional themes in disparate structural surroundings

被引：282

作者：

Lowther, WT

Matthews, BW

机构：

[1] Howard Hughes Med Inst, Inst Mol Biol, Eugene, OR 97403 USA

[2] Univ Oregon, Dept Phys, Eugene, OR 97403 USA

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 12期

关键词：

D O I：

10.1021/cr0101757

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metalloaminopeptidases... This review describes the contributions of many laboratories as they have sought to understand the molecular basis for substrate specificity and catalysis. An effort is made to give sufficient historical background to appreciate the current state of knowledge. The structure-function relationships for each enzyme system are presented based on the analysis of substrate specificity, metal dependence, and the comparison of ligand complexes determined by X-ray crystallography, when available.

引用

收藏

页码：4581 / 4607

页数：27

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