CARMA1, BCL-10 and MALT1 in lymphocyte development and activation

被引：303

作者：

Thome, M ^{[1
]}

机构：

[1] Univ Lausanne, Dept Biochem, BIL Biomed Res Ctr, CH-1066 Epalinges, Switzerland

来源：

NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 05期

关键词：

D O I：

10.1038/nri1352

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CARMA1, BCL-10 and MALT1 are signalling proteins that have a key role in antigen-receptor-mediated lymphocyte activation through the nuclear factor-kappaB pathway. Recent genetic studies have revealed additional, previously unexpected roles for these proteins in the development of B and T cells, and in the CD40- and lipopolysaccharide-dependent activation of B cells. Here, I discuss recent advances in the understanding of the molecular and biological functions of these proteins.

引用

页码：348 / 359

页数：12

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