The co-evolution of host cationic antimicrobial peptides and microbial resistance

被引：832

作者：

Peschel, Andreas ^{[1
]}

Sahl, Hans-Georg

机构：

[1] Univ Tubingen, Cellular & Mol Microbiol Div, Med Microbiol & Hyg Dept, D-72076 Tubingen, Germany

[2] Univ Bonn, Dept Med Microbiol Immunol & Parasitol, Pharmaceut Microbiol Unit, D-53115 Bonn, Germany

来源：

NATURE REVIEWS MICROBIOLOGY | 2006年 / 4卷 / 07期

关键词：

D O I：

10.1038/nrmicro1441

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Endogenous cationic antimicrobial peptides (CAMPs) are among the most ancient and efficient components of host defence. It is somewhat of an enigma that bacteria have not developed highly effective CAMP-resistance mechanisms, such as those that inhibit many therapeutic antibiotics. Here, we propose that CAMPs and CAMP-resistance mechanisms have co-evolved, leading to a transient host-pathogen balance that has shaped the existing CAMP repertoire. Elucidating the underlying principles of this process could help in the development of more sustainable antibiotics.

引用

页码：529 / 536

页数：8

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