3-[2-(pyrrolidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)propyl]indoles: Agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B subtype

被引:17
作者
Castro, JL [1 ]
Street, LJ [1 ]
Guiblin, AR [1 ]
Jelley, RA [1 ]
Russell, MGN [1 ]
Sternfeld, F [1 ]
Beer, MS [1 ]
Stanton, JA [1 ]
Matassa, VG [1 ]
机构
[1] MERCK SHARP & DOHME LTD,RES LABS,NEUROSCI RES CTR,DEPT BIOCHEM,HARLOW CM20 2QR,ESSEX,ENGLAND
关键词
D O I
10.1021/jm9704558
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:3497 / 3500
页数:6
相关论文
共 24 条
[1]   5-HT RECEPTORS MEDIATING CONTRACTIONS OF THE ISOLATED HUMAN CORONARY-ARTERY [J].
BAX, WA ;
RENZENBRINK, GJ ;
VANHEUVENNOLSEN, D ;
THIJSSEN, EJM ;
BOS, E ;
SAXENA, PR .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 239 (1-3) :203-210
[2]  
Bouchelet I, 1996, MOL PHARMACOL, V50, P219
[3]   Modeling of the agonist binding site of serotonin human 5-HT1A, 5-HT1D alpha and 5-HT1D beta receptors [J].
Bremner, DH ;
Ringan, NS ;
Wishart, G .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1997, 32 (01) :59-69
[4]  
CASTRO JL, 1996, Patent No. 4274
[5]   SYNTHESIS OF THE 5-HT1D RECEPTOR AGONIST MK-0462 VIA A PD-CATALYZED COUPLING REACTION [J].
CHEN, CY ;
LIEBERMAN, DR ;
LARSEN, RD ;
REAMER, RA ;
VERHOEVEN, TR ;
REIDER, PJ ;
COTTRELL, IF ;
HOUGHTON, PG .
TETRAHEDRON LETTERS, 1994, 35 (38) :6981-6984
[6]   Pilot study of MK-462 in migraine [J].
Cutler, NR ;
Claghorn, J ;
Sramek, JJ ;
Block, G ;
Panebianco, D ;
Cheng, H ;
Olah, TV ;
Reines, SA .
CEPHALALGIA, 1996, 16 (02) :113-116
[7]  
Ferrari M D, 1993, Neurology, V43, pS43
[8]   CLINICAL AND EXPERIMENTAL EFFECTS OF SUMATRIPTAN IN HUMANS [J].
FERRARI, MD ;
SAXENA, PR .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1993, 14 (04) :129-133
[9]   A COMPARISON OF THE CONTRACTILE EFFECTS OF 5-HYDROXYTRYPTAMINE, SUMATRIPTAN AND MK-462 ON HUMAN CORONARY-ARTERY IN-VITRO [J].
FERRO, A ;
LONGMORE, J ;
HILL, RG ;
BROWN, MJ .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1995, 40 (03) :245-251
[10]  
HAMEL E, 1993, MOL PHARMACOL, V44, P242