Synthesis of a novel spiro bisphosphinamidite ligand for highly enantioselective hydrogenation

被引：29

作者：

Lin, CW ^{[1
]}

Lin, CC ^{[1
]}

Lam, LFL ^{[1
]}

Au-Yeung, TTL ^{[1
]}

Chan, ASC ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 39期

关键词：

D O I：

10.1016/j.tetlet.2004.07.137

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel chiral bisphosphinamidite ligand SpiroNP has been synthesized. The rhodium complex of this ligand has been found to be highly active and enantioselective in the asymmetric hydrogenation of (Z)-2-acetamidoacrylic acid derivatives and alpha,beta-unsaturated carboxylic acid derivatives. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：7379 / 7381

页数：3

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