PRISM: a web server and repository for prediction of protein-protein interactions and modeling their 3D complexes

被引:137
作者
Baspinar, Alper [1 ,2 ]
Cukuroglu, Engin [1 ,2 ]
Nussinov, Ruth [3 ,4 ]
Keskin, Ozlem [1 ,2 ]
Gursoy, Attila [1 ,2 ]
机构
[1] Koc Univ, Ctr Computat Biol & Bioinformat, TR-34450 Istanbul, Turkey
[2] Koc Univ, Coll Engn, TR-34450 Istanbul, Turkey
[3] NCI, Canc & Inflammat Program, Frederick Natl Lab Canc Res, Leidos Biomed Res Inc, Frederick, MD 21702 USA
[4] Tel Aviv Univ, Sackler Inst Mol Med, Sackler Sch Med, Dept Human Genet & Mol Med, IL-69978 Tel Aviv, Israel
基金
美国国家卫生研究院;
关键词
HOT-SPOTS; INTERFACES; SCALE; DOCKING; REFINEMENT; NETWORKS;
D O I
10.1093/nar/gku397
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The PRISM web server enables fast and accurate prediction of protein-protein interactions (PPIs). The prediction algorithm is knowledge-based. It combines structural similarity and accounts for evolutionary conservation in the template interfaces. The predicted models are stored in its repository. Given two protein structures, PRISM will provide a structural model of their complex if a matching template interface is available. Users can download the complex structure, retrieve the interface residues and visualize the complex model.
引用
收藏
页码:W285 / W289
页数:5
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