Ibogaine pretreatment dramatically enhances the dynorphin response to cocaine

被引：5

作者：

Alburges, ME ^{[1
]}

Hanson, GR ^{[1
]}

机构：

[1] Univ Utah, Coll Pharm, Dept Pharmacol & Toxicol, Salt Lake City, UT 84112 USA

来源：

BRAIN RESEARCH | 1999年 / 847卷 / 01期

关键词：

ibogaine; cocaine; dynorphin; neurotensin; striatum; nucleus accumbens;

D O I：

10.1016/S0006-8993(99)02017-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ibogaine (Endabuse(TM)) is a psychoactive indole alkaloid found in the shrub, Tabernanthe iboga, which has been used to treat stimulant addiction. Because ibogaine influences the activity of neurotensin systems, a dopamine-linked neuropeptide, the present study investigated if ibogaine also influences dynorphin (DYN) pathways. Unlike neurotensin responses, ibogaine alone did not alter DYN levels in the striatum, substantia nigra or nucleus accumbens. Interestingly, ibogaine pretreatment dramatically enhanced cocaine-induced increases in DYN content in these structures. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：139 / 142

页数：4

共 18 条

[11] IBOGAINE REDUCES PREFERENCE FOR COCAINE CONSUMPTION IN C57BL/6BY MICE [J].

SERSHEN, H ;

HASHIM, A ;

LAJTHA, A .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1994, 47 (01) :13-19

[12] IBOGAINE ANTAGONIZES COCAINE-INDUCED LOCOMOTOR STIMULATION IN MICE [J].

SERSHEN, H ;

HASHIM, A ;

HARSING, L ;

LAJTHA, A .

LIFE SCIENCES, 1992, 50 (15) :1079-1086

[13] EFFECT OF IBOGAINE ON SEROTONERGIC AND DOPAMINERGIC INTERACTIONS IN STRIATUM FROM MICE AND RATS [J].

SERSHEN, H ;

HASHIM, A ;

LAJTHA, A .

NEUROCHEMICAL RESEARCH, 1994, 19 (11) :1463-1466

[14] A PRELIMINARY INVESTIGATION OF IBOGAINE - CASE-REPORTS AND RECOMMENDATIONS FOR FURTHER STUDY [J].

SHEPPARD, SG .

JOURNAL OF SUBSTANCE ABUSE TREATMENT, 1994, 11 (04) :379-385

[15]

Sisko B., 1993, MULTIDISCIPLINARY AS, VIV, P15

[16]

SMILEY PL, 1990, J PHARMACOL EXP THER, V253, P938

[17] Regulation of kappa opioid receptor mRNA in the rat brain by 'binge' pattern cocaine administration and correlation with preprodynorphin mRNA [J].

Spangler, R ;

Ho, A ;

Zhou, Y ;

Maggos, CE ;

Yuferov, V ;

Kreek, MJ .

MOLECULAR BRAIN RESEARCH, 1996, 38 (01) :71-76

[18] COCAINE-INDUCED C-FOS MESSENGER-RNA IS INVERSELY RELATED TO DYNORPHIN EXPRESSION IN STRIATUM [J].

STEINER, H ;

GERFEN, CR .

JOURNAL OF NEUROSCIENCE, 1993, 13 (12) :5066-5081

← 1 2 →