Gold(I)-catalyzed conia-ene reaction of β-ketoesters with alkynes

被引：392

作者：

Kennedy-Smith, JJ ^{[1
]}

Staben, ST ^{[1
]}

Toste, FD ^{[1
]}

机构：

[1] Univ Calif Berkeley, Ctr New Direct Organ Synth, Dept Chem, Berkeley, CA 94720 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 14期

关键词：

D O I：

10.1021/ja049487s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The intramolecular addition of β-ketoesters to unactivated alkynes under neutral conditions and at room temperature is described. The method employs triphenylphosphinegold(I) cation as a catalyst for the formation of exo-methylenecycloalkanes. Both monocyclic and bicyclic cyclopentanes and cyclohexanes can be formed in excellent yields and with good diastereoselectivity. Copyright © 2004 American Chemical Society.

引用

页码：4526 / 4527

页数：2

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