Gold(I)-catalyzed conia-ene reaction of β-ketoesters with alkynes

被引:392
作者
Kennedy-Smith, JJ [1 ]
Staben, ST [1 ]
Toste, FD [1 ]
机构
[1] Univ Calif Berkeley, Ctr New Direct Organ Synth, Dept Chem, Berkeley, CA 94720 USA
关键词
D O I
10.1021/ja049487s
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The intramolecular addition of β-ketoesters to unactivated alkynes under neutral conditions and at room temperature is described. The method employs triphenylphosphinegold(I) cation as a catalyst for the formation of exo-methylenecycloalkanes. Both monocyclic and bicyclic cyclopentanes and cyclohexanes can be formed in excellent yields and with good diastereoselectivity. Copyright © 2004 American Chemical Society.
引用
收藏
页码:4526 / 4527
页数:2
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