Enantioselective Heterogeneous Synergistic Catalysis for Asymmetric Cascade Transformations

被引：45

作者：

Deiana, Luca ^{[2
,3
]}

Ghisu, Lorenza ^{[2
,3
]}

Afewerki, Samson ^{[1
]}

Verho, Oscar ^{[2
,3
]}

Johnston, Eric V. ^{[2
,3
]}

Hedin, Niklas ^{[3
,4
]}

Bacsik, Zoltan ^{[4
]}

Cordova, Armando ^{[1
,2
,3
]}

机构：

[1] Mid Sweden Univ, Dept Nat Sci Engn & Math, SE-85170 Sundsvall, Sweden

[2] Stockholm Univ, Dept Organ Chem, Arrhenius Lab, S-10691 Stockholm, Sweden

[3] Stockholm Univ, Berzelii Ctr EXSELENT, SE-10691 Stockholm, Sweden

[4] Stockholm Univ, Dept Mat & Environm Chem, SE-10691 Stockholm, Sweden

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2014年 / 356卷 / 11-12期

关键词：

all-carbon quaternary stereocenters; carbocycles; co-catalysis; dynamic transformations; heterogeneous synergistic catalysis; MESOPOROUS SILICA; TRANSITION-METAL; COOPERATIVE CATALYSIS; CLICK CHEMISTRY; BASIC SITES; AMINE; CONSTRUCTION; NANOPARTICLES; POT; CARBOCYCLIZATION;

D O I：

10.1002/adsc.201400291

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A modular design for a novel heterogeneous synergistic catalytic system, which simultaneously activates the electrophile and nucleophile by the combined activation modes of a separate metal and non-metal catalyst, for asymmetric cascade transformations on a solid surface is disclosed. This modular catalysis strategy generates carbocycles (up to 97.5: 2.5 er) as well as spirocyclic oxindoles (97.5: 2.5 to > 99: 0.5 er), containing all-carbon quaternary centers, in a highly enantioselective fashion via a one-pot dynamic relay process.

引用

页码：2485 / 2492

页数：8

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