A family of chromatin remodeling factors related to Williams syndrome transcription factor

被引：128

作者：

Bochar, DA

Savard, J

Wang, WD

Lafleur, DW

Moore, P

Côté, J

Shiekhattar, R

机构：

[1] Wistar Inst, Philadelphia, PA 19104 USA

[2] Univ Laval, Hotel Dieu, Ctr Canc Res, Quebec City, PQ G1R 2J6, Canada

[3] NIA, Genet Lab, NIH, Gerontol Res Ctr, Baltimore, MD 21224 USA

[4] Human Genome Sci Inc, Dept Biol Mol, Rockville, MD 20874 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 03期

关键词：

D O I：

10.1073/pnas.97.3.1038

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report the isolation of WCRF, a new chromatin-remodeling complex from HeLa cells. WCRF is composed of two subunits, WCRF135, the human homolog of Drosophila ISWI, and WCRF180, a protein related to the Williams syndrome transcription factor. WCRF180 is a member of a family of proteins sharing a putative heterochromatin localization domain, a PHD finger, and a bromodomain, prevalent in factors involved in regulation of chromatin structure.

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页码：1038 / 1043

页数：6

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