Positive strand RNA viral genomes are unique in the viral world in serving a dual role as mRNA and replicon. Since the origin of the minus-strand RNA replication intermediate is at the 3'-end of the genome, the 3'-untranslated region (UTR) clearly plays a role in viral RNA replication. The messenger role of this same RNA likely places functional demands on the 3'-UTR to serve roles typical of cellular mRNAs, including the regulation of RNA stability and translation. Current understanding indicates varied roles for positive strand RNA viral 3'-UTRs, with the dominant roles differing between viruses. Three case studies are discussed: turnip yellow mosaic virus RNA, whose 3' tRNA mimicry is thought to negatively regulate minus strand synthesis; brome mosaic virus, whose 3'-UTR contains a unique promoter element directing minus strand synthesis; and tobacco mosaic virus, whose 3'-UTR contains an enhancer of translational expression.
机构:
Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
Gamarnik, AV
Andino, R
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
机构:
Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
Gamarnik, AV
Andino, R
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA