Influence of monoamine oxidase A and serotonin receptor 2A polymorphisms in SSRI antidepressant activity

被引：85

作者：

Cusin, C ^{[1
]}

Serretti, A ^{[1
]}

Zanardi, R ^{[1
]}

Lattuada, E ^{[1
]}

Rossini, D ^{[1
]}

Lilli, R ^{[1
]}

Lorenzi, C ^{[1
]}

Smeraldi, E ^{[1
]}

机构：

[1] Ist Sci San Raffaele, Dept Psychiat, Fdn Ctr San Raffaele Monte Tabor, I-20127 Milan, Italy

来源：

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2002年 / 5卷 / 01期

关键词：

antidepressant treatment; fluvoxamine; mood disorders; paroxetine; pharmacogenetics; pindolol;

D O I：

10.1017/S1461145701002711

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of the present study was to test a possible effect of the monoamine oxidase A (MAOA) and serotonin receptor 2A (5-HT-2A) gene variants on the antidepressant activity of fluvoxamine and paroxetine in a sample of major (n = 248) and bipolar (n = 195) depressives, with or without psychotic features. A total of 443 inpatients were treated with 300 mg fluvoxamine (n = 307) or 20-40 mg paroxetine (n = 136) for 6 wk. The severity of depressive symptoms was assessed weekly with the Hamilton Rating Scale for Depression (HAMD). Allele variants were determined in each subject using a PCR-based technique. We observed a marginal association between 5-HT-2A variants and antidepressant response while MAOA genotypes were not associated. Possible stratification factors, such as sex, diagnosis, presence of psychotic features, HAMD scores at baseline, pindolol augmentation and SSRIs plasma levels did not significantly influence the observed results. The investigated MAOA and 5-HT-2A gene variants, therefore, do not seem to play a major role in SSRI antidepressant activity.

引用

页码：27 / 35

页数：9

共 70 条

[21]

GIBBONS RD, 1993, ARCH GEN PSYCHIAT, V50, P739

[22]

Glennon R.A., 1995, PSYCHOPHARMACOLOGY 4

[23] Genetic variation of the 5-HT2A receptor gene and bipolar affective disorder [J].

Gutierrez, B ;

Bertranpetit, J ;

Collier, D ;

Arranz, MJ ;

Valles, V ;

Guillamat, R ;

VanOs, J ;

Fananas, L .

HUMAN GENETICS, 1997, 100 (5-6) :582-584

[24]

Hamilton M., 1967, British Journal of Social and Clinical Psychology, V6, P278

[25] MIXREG: A computer program for mixed-effects regression analysis with autocorrelated errors [J].

Hedeker, D ;

Gibbons, RD .

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, 1996, 49 (03) :229-252

[26] CHARACTERIZATION OF A HIGHLY POLYMORPHIC REGION NEAR THE 1ST EXON OF THE HUMAN MAOA GENE CONTAINING A GT DINUCLEOTIDE AND A NOVEL VNTR MOTIF [J].

HINDS, HL ;

HENDRIKS, RW ;

CRAIG, IW ;

CHEN, ZY .

GENOMICS, 1992, 13 (03) :896-897

[27]

HOTAMISLIGIL GS, 1991, AM J HUM GENET, V49, P383

[28] STRUCTURAL FEATURES OF HUMAN MONOAMINE OXIDASE-A ELUCIDATED FROM CDNA AND PEPTIDE SEQUENCES [J].

HSU, YPP ;

WEYLER, W ;

SHIUAN, C ;

SIMS, KB ;

RINEHART, WB ;

UTTERBACK, MC ;

POWELL, JF ;

BREAKEFIELD, XO .

JOURNAL OF NEUROCHEMISTRY, 1988, 51 (04) :1321-1324

[29] Serotonin transporter gene polymorphism and antidepressant response [J].

Kim, DK ;

Lim, SW ;

Lee, S ;

Sohn, SE ;

Kim, S ;

Hahn, CG ;

Carroll, BJ .

NEUROREPORT, 2000, 11 (01) :215-219

[30] A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders [J].

Kunugi, H ;

Ishida, S ;

Kato, T ;

Tatsumi, M ;

Sakai, T ;

Hattori, M ;

Hirose, T ;

Nanko, S .

MOLECULAR PSYCHIATRY, 1999, 4 (04) :393-395

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