Production of morphology-controllable porous hyaluronic acid particles using a spray-drying method

被引：60

作者：

Iskandar, Ferry ^{[1
]}

Nandiyanto, Asep Bayu Dani ^{[1
]}

Widiyastuti, W. ^{[1
]}

Young, Lee Sin ^{[1
]}

Okuyama, Kikuo ^{[1
]}

Gradon, Leon ^{[2
]}

机构：

[1] Hiroshima Univ, Grad Sch Engn, Dept Chem Engn, Higashihiroshima 7398527, Japan

[2] Warsaw Univ Technol, Dept Chem Engn, PL-00645 Warsaw, Poland

来源：

ACTA BIOMATERIALIA | 2009年 / 5卷 / 04期

关键词：

Hyaluronic acid; Etching; Aerodynamic diameter; Spray-drying method; Particle pores; EXERCISE-INDUCED BRONCHOCONSTRICTION; PULMONARY DRUG-DELIVERY; NANOSTRUCTURED PARTICLES; POWDER STRUCTURES; SILICA PARTICLES; INHALATION; DEPOSITION; SIZE; REENTRAINMENT; POLYSTYRENE;

D O I：

10.1016/j.actbio.2008.11.016

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Hyaluronic acid (HA) porous particles with controllable porosity and pore size, ranging from 100 to 300 nm, were successfully prepared using a colloidal templating and spray-drying method. HA powder and polystyrene latex (PSL) particles, which were used as the precursor and templating agent, respectively, were mixed in aqueous solution and spray-dried using a two-fluid nozzle system to produce HA and PSL composite particles. Water was evaporated during spray-drying using heated air with a temperature of 120 degrees C. This simple process was completed within several seconds. The prepared particles were collected and washed with an organic solvent to dissolve the PSL templating agent. The porosity and pore size of the resulting particles were easily controlled by changing the initial mass ratio of precursor to templating agent, i.e., HA to PSL, and by altering the size of the PSL template particles. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：1027 / 1034

页数：8

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