Hitting the target with bifunctional phage

被引：3

作者：

Brown, KC ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Internal Med, Ctr Biomed Invent, Dallas, TX 75390 USA

来源：

CHEMISTRY & BIOLOGY | 2004年 / 11卷 / 08期

关键词：

D O I：

10.1016/j.chembiol.2004.08.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peptide libraries are rich sources of cell-targeting peptides. In this issue of Chemistry & Biology, Pasqualini and coworkers have developed a chimeric cell-targeting phage system that can easily be modified to delivery of a variety of reagents without need for chemical conjugation [1].

引用

页码：1033 / 1035

页数：3

共 22 条

[11]

Larocca D, 2002, Methods Mol Biol, V185, P393

[12] PHOPHABS - ANTIBODY-PHAGE-ALKALINE PHOSPHATASE CONJUGATES FOR ONE-STEP ELISA WITHOUT IMMUNIZATION [J].

LIGHT, J ;

LERNER, RA .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (09) :1073-1078

[13]

MCGUIRE MJ, 2004, IN PRESS J MOL BIOL

[14]

MCGUIRE MJ, 2004, IN PRESS DNA CELL BI

[15] Isolation of lung tumor specific peptides from a random peptide library: generation of diagnostic and cell-targeting reagents [J].

Oyama, T ;

Sykes, KF ;

Samli, KN ;

Minna, JD ;

Johnston, SA ;

Brown, KC .

CANCER LETTERS, 2003, 202 (02) :219-230

[16] alpha v Integrins as receptors for tumor targeting by circulating ligands [J].

Pasqualini, R ;

Koivunen, E ;

Ruoslahti, E .

NATURE BIOTECHNOLOGY, 1997, 15 (06) :542-546

[17] Organ targeting in vivo using phage display peptide libraries [J].

Pasqualini, R ;

Ruoslahti, E .

NATURE, 1996, 380 (6572) :364-366

[18] Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display [J].

Rajotte, D ;

Arap, W ;

Hagedorn, M ;

Koivunen, E ;

Pasqualini, R ;

Ruoslahti, E .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (02) :430-437

[19] Identification of novel carrier peptides for the specific delivery of therapeutics into cancer cells [J].

Shadidi, M ;

Sioud, M .

FASEB JOURNAL, 2002, 16 (14) :256-+

[20] In vivo phage display and vascular heterogeneity:: implications for targeted medicine [J].

Trepel, M ;

Arap, W ;

Pasqualini, R .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (03) :399-404

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