PHOPHABS - ANTIBODY-PHAGE-ALKALINE PHOSPHATASE CONJUGATES FOR ONE-STEP ELISA WITHOUT IMMUNIZATION

被引：18

作者：

LIGHT, J ^{[1
]}

LERNER, RA ^{[1
]}

机构：

[1] SCRIPPS RES INST, DEPT MOLEC BIOL & CHEM, LA JOLLA, CA 92037 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)80621-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

PhoPhabs have been created by incorporating alkaline phosphatase and antibody Fab's from combinatorial libraries on a filamentous phage framework. These PhoPhabs are antigen specific and can replace antibodies and eliminate the need for immunizations in ELISA (enzyme linked immunoabsorbent) methods.

引用

页码：1073 / 1078

页数：6

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