A Self-Assembled Albumin-Based Nanoprobe for In Vivo Ratiometric Photoacoustic pH Imaging

被引：349

作者：

Chen, Qian ^{[1
]}

Liu, Xiaodong ^{[2
]}

Chen, Jiawen ^{[1
]}

Zeng, Jianfeng ^{[3
]}

Cheng, Zhenping ^{[2
]}

Liu, Zhuang ^{[1
]}

机构：

[1] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China

[2] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Jiangsu Key Lab Adv Funct Polymer Design & Applic, Dept Polymer Sci & Engn, Suzhou 215123, Jiangsu, Peoples R China

[3] Soochow Univ, Coll Med, Sch Radiat Med & Protect, Suzhou 215123, Jiangsu, Peoples R China

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 43期

基金：

中国国家自然科学基金;

关键词：

UP-CONVERSION NANOPARTICLES; THERAPY; AGENT; MICROENVIRONMENT; GLYCOPROTEIN; DYE;

D O I：

10.1002/adma.201503194

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A photoacoustic nanoprobe is self-assembled from human serum albumin and two types of dye molecules, one is inert to pH and the other is pH sensitive. This probe and the quantitative ratiometric photoacoustic pH imaging method are shown to have high safety, be easy-to-operate, and have depth-independent accuracy for real-time in vivo pH imaging of entire tumors. These features make them promising for future cancer prognosis and therapeutic planning.

引用

收藏

页码：6820 / +

页数：9

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