Targeting of Smoothened for therapeutic gain

被引：95

作者：

Ruat, Martial ^{[1
]}

Hoch, Lucile ^{[1
]}

Faure, Helene ^{[1
]}

Rognan, Didier ^{[2
]}

机构：

[1] CNRS, Alfred Fessard Inst Neurobiol, Lab Neurobiol & Dev, UPR 3294,Signal Transduct & Dev Neuropharmacol Te, F-91198 Gif Sur Yvette, France

[2] MEDALIS Drug Discovery Ctr, Lab Innovat Therapeut, UMR 7200, F-67400 Illkirch Graffenstaden, France

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2014年 / 35卷 / 05期

关键词：

Hedgehog; stem cell; neurodegenerative disease; cancer; bias agonism; HEDGEHOG PATHWAY INHIBITOR; SONIC HEDGEHOG; SIGNALING PATHWAY; PRIMARY CILIA; ACTIVATION; MEDULLOBLASTOMA; BINDING; CANCER; REQUIREMENT; MECHANISMS;

D O I：

10.1016/j.tips.2014.03.002

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The Smoothened (Smo) receptor is a key transducer of the Hedgehog (Hh) signaling pathway, which plays a critical role in tissue maintenance and repair. Recent studies have highlighted the therapeutic value of Smo antagonists for treating Hh-linked cancers. Research on Smo agonists indicates that these molecules are important not only for delineating canonical versus noncanonical Hh signaling but also for understanding the role of Smo in physiological and pathological conditions. This review provides an update on the potential therapeutic importance of Smo modulators, and unravels the increasing complexity of its pharmacology with regard to clinical implications.

引用

收藏

页码：237 / 246

页数：10

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